Teacher: Maurizio Mattei
Aims: Purpose of the course is to provide students with tools needed to define the different pathologic conditions in relation to the underlying causes and main pathogenic mechanisms, operating at the cellular, tissue and systemic levels. The knowledge acquired during the course is a prerequisite for a rational approach to biotechnology applications in clinical settings and for the critical evaluation of clinically relevant experimental data.
Program: Cellular adaptations and responses to stress. Cell death. Overview of repair responses after injury and inflammation. Regeneration and fibrosis. Hemostasis disorders. Hemodynamic disorders. Thrombosis, embolism. Infarction. Shock. Hypertension, atherosclerosis. Heart pathophysiology. Heart failure. Cardiac hypertrophy. Ischemic heart disease. Angina pectoris. Myocardial infarction. Red blood cell disorders. Anemia. Classification of anemia. Decreased red blood cell production. Hemolytic anemias. Blood loss anemia. Liver pathophysiology. Hepatic failure. Cirrhosis. Portal hypertension. Ascites. Viral hepatitis. Bilirubin metabolism. Causes and classification of jaundice. Respiratory pathophysiology. Respiratory failure: causes and classification. Respiratory distress syndromes. Chronic obstructive pulmonary diseases. Interstitial lung disease. Kidney patophysiology. Acute renal failure and chronic renal failure. Nephritic syndrome and nephrotic syndrome. Glomerulonephritis. Tubulo-interstitial diseases. Obstructive diseases.
Endocrine system pathophysiology. General mechanisms of hormonal hypofunction and hyperfunction. Diabetes mellitus. Diabetes insipidus.
Suggested textbooks: Robbins & Cotran. Pathologic Basis of Disease; Rubin’s Pathology: Clinicopathologic Foundations of Medicine
