Teacher: Antonella Messore
Aims: This course leads students towards the learning of drug invention, starting from banch drug discovery, to the applied research, drug development up to the marketing. To understand deeply the pharmacodynamics and pharmacokinetic principles underlying the drug design and development process. Moreover, special focus will be on regulatory affairs legislation and the complex procedures for a drug candidate to fill the safety requirements and efficacy that National and European Regulatory Agencies require for authorization.
Program: Drug History. Drug Discovery Phases. Medicinal Chemistry: Target – (Enzymes, Receptors, Ion Channels, Transporters). Hit identification – hit to lead – lead to candidate. Pharmacodynamics and mechanism of Drug-Target Interaction. Pharmacokinetics. Rational Drug Design (Structure Activity Relationship, Pharmacophore, Bioisosterism, Chemical Modifications, Lead optimization Strategies). Computer Aided Drug Design (Ligand and Structure Based Approaches, Pharmacophore Screening, Database Virtual Screening, Docking). Combichem Approaches in Drug Discovery (Combinatorial Synthesis, Parallel Synthesis Methodologies).
